![]() An estimated 800 000 Americans-and potentially more than 4 million-use heroin and/or synthetic opioids 40%–70% of heroin users report having injected in the past year. The United States’ 3-decade long opioid crisis has unfolded in 3 phases with increasing opioid analgesic use and misuse beginning in the 1990s leading to greater heroin use after 2007 and skyrocketing rates of overdoses from synthetic opioids (eg, fentanyl) after 2013. Endocarditis, OPAT, opioid use disorder, substance use disorder
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